Estelle MEZIANI : Experimental investigation of shear stress induced by cavitation bubbles
Laboratories : LabTau et LMFA
Thesis directors : Claude Inserra
Thesis supervisors : Philippe Blanc-Benon et Cyril Mauger
Summary :
When a cavitation bubble is subjected to an acoustic field, it oscillates around its equilibrium position. However, beyond a certain threshold, the increase in acoustic pressure induces non-linear oscillation modes : the bubble no longer oscillates spherically. In a context of targeted drug delivery, the control of oscillating bubbles allows the control of the permeability of cell membranes (sonoporation phenomenon) and thus the introduction of drugs inside them. It is then important to control and quantify the effect of the flow induced by the bubble on the cell wall in order to not damage it. The objective of this thesis is to study the 3D flow generated by an oscillating bubble and to quantify the shear stresses induced on a surrounding wall.