Estelle MEZIANI : Experimental investigation of shear stress induced by cavitation bubbles

from 01/10/2021 to 30/09/2024

Laboratories : LabTau et LMFA Thesis directors : Claude Inserra Thesis supervisors : Philippe Blanc-Benon et Cyril Mauger

Summary :
When a cavitation bubble is subjected to an acoustic field, it oscillates around its equilibrium position. However, beyond a certain threshold, the increase in acoustic pressure induces non-linear oscillation modes : the bubble no longer oscillates spherically. In a context of targeted drug delivery, the control of oscillating bubbles allows the control of the permeability of cell membranes (sonoporation phenomenon) and thus the introduction of drugs inside them. It is then important to control and quantify the effect of the flow induced by the bubble on the cell wall in order to not damage it. The objective of this thesis is to study the 3D flow generated by an oscillating bubble and to quantify the shear stresses induced on a surrounding wall.